MK-4541
CAS No. : 796885-38-6
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| Cat. No. : | HY-125065 |
| M.Wt: | 428.49 |
| Formula: | C22H31F3N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model[1].
In Vivo:MK-4541 (100 mg/kg; p.o.; 5 times per week for 5 weeks) inhibits prostate tumor growth in athymic nude mice bearing R-3327-G cells[1].
MK-4541 (100 mg/kg, 200 mg/kg; p.o.; 5 times per week for 5 weeks) exhibits anti-androgen effects on the seminal vesicles, reduces plasma testosterone concentrations in intact males, and inhibits Ki67 expression[1].
MK-4541 (15 mg/kg, 50 mg/kg; p.o.; 5 times per week for 8 weeks) causes the loss of musculoskeletal mass and function in adult castrated mice[1].
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