Fluazinam

Fluazinam is an orally active dinitroaniline fungicide. Fluazinam induces phosphorylation of JNK, activates p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees^{[1][2][3][4][5][6][7]}. IC50 & Target:Fungal^[1] In Vitro:Fluazinam (0-5 μM; 24 h) induces SH-SY5Y cell death and nuclear damage^[1].
Fluazinam (10-20 μg/mL) has great control efficiency against B. maydis on detached corn leaves^[2].
Fluazinam has strong antifungal activity against F. fujikuroi, with EC₅₀ values ranging from 0.0621 to 0.5446 μg/mL for mycelial growth inhibition of 103 F. fujikuroi isolates^[3].
Fluazinam (0.01-0.5 μM) impairs oxidative phosphorylation and induces hyper/hypo-activity in a dose specific manner in zebrafish larvae^[4].
Fluazinam (0.03-0.40 mg/L; 24-96 h) has acute toxicity to Brachydanio rerio^[5].
In Vivo:Fluazinam (0.5-2.5 mg a.i. mL^-1; oral exposure; 24 h) reduces food consumption, damages the midgut epithelium, increases autophagy and apoptosis in the midgut, induces oxidative stress, and alters the walking behavior in Partamona helleri worker bees^[6].