Sertraline (hydrochloride)
CAS No. : 79559-97-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $72 | In-stock |
| 50mg | $230 | In-stock |
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| Cat. No. : | HY-B0176A |
| M.Wt: | 342.69 |
| Formula: | C17H18Cl3N |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 2.86 mg/mL (ultrasonic;warming;heat to 60°C) |
Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].
In Vitro: Sertraline (1 μM, 12 hours) inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor-α (TNF-α)-induced microglial activation and inflammatory mediator production in microglia[3].
Sertraline (1 μM) inhibits the HMGB1/toll-like receptor 4 (TLR4)- and TNF-α/TNF receptor 1 (TNFR1)-mediated nuclear factor-kappa B (NF-κB) activation in HMGB1- or TNF-α-stimulated microglia[3].
In Vivo: Sertraline (10 mg/kg) is shown to produce the optimal anti-depression effectsin chronic unpredictable mild stress (CUMS)-exposed mice[3].
Sertraline (10 mg/kg; a single i.p.) significantly reduces the immobility time during forced swim test (FST) in all female animals[4].
Sertraline (10 mg/kg; a single i.p.) does not alter spontaneous locomotor activity in all three genotypes regardless of sex difference[4].
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