360A
CAS No. : 794458-56-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | Get quote |
| 5mg | $275 | Get quote |
| 10 mg | Get quote | |
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| Cat. No. : | HY-15595 |
| M.Wt: | 449.50 |
| Formula: | C27H23N5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
IC50 & Target: IC50: 300 nM (Telomerase)[1]
G-quadruplex[1]
In Vitro: 360A inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively[1]. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions[2].
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