Nocloprost
CAS No. : 79360-43-3
| Size | Price | Stock |
|---|---|---|
| 500μg | $389 | Get quote |
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| Cat. No. : | HY-106054 |
| M.Wt: | 400.98 |
| Formula: | C22H37ClO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nocloprost, a prostaglandin E2 (PGE2) analog, is an orally active EP1- and EP3-receptor agonist. Nocloprost inhibits evoked [3H]ACh release. Nocloprost has gastroprotective and ulcer-healing properties. Nocloprost accelerates the healing of chronic gastric ulcerations and enhances mucosal growth in rats[1][2].
In Vivo:Nocloprost (intragastrically; 0.01-10 μg/kg) 30 min before 100% ethanol, acidified Aspirin (HY-14654), acidified Taurocholate (HY-N0545), water immersion, or restraint stress dose dependently prevents the formation of gastric lesions in rats[1].
Nocloprost (i.g.; 0.01-100 μg/kg) failes to affect gastric acid secretion or intestinal secretion (enteropooling) but preventes the increased gastroduodenal alkaline secretion[1].
Nocloprost (s.c.) shows protective activity against ethanol damage but is ineffective when applied intraduodenally[1].
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