Azelastine (hydrochloride)
CAS No. : 79307-93-0
| Size | Price | Stock |
|---|---|---|
| 100mg | $50 | In-stock |
| 200mg | $69 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-B0462 |
| M.Wt: | 418.36 |
| Formula: | C22H25Cl2N3O |
| Purity: | >98 % |
| Solubility: | H2O : 6.67 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
Azelastine hydrochloridem, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine hydrochloride can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].
IC50 & Target:H1 receptor[1]
In Vitro: Azelastine hydrochloride can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling[5].
In Vivo: Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model[2].
Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model[2].
Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model[2].
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