ER-000444793
CAS No. : 792957-74-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $88 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $600 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1350 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100852 |
| M.Wt: | 354.40 |
| Formula: | C23H18N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. ER-000444793 inhibits mPTP with an IC50 of 2.8 μM. IC50 & Target: IC50: 2.8 μM (mPTP)[1] In Vitro: ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. ER-000444793 potently and dose-dependently inhibits Ca2+-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC50=23 nM and SfA IC50= 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled-CsA from rhCypD protein. Together, these data suggest the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition[1].
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