Fluazifop-P-butyl

Fluazifop-P-butyl is an orally active herbicide and ACCase inhibitor. Fluazifop-P-butyl blocks the formation of malonyl-CoA, disrupts lipid synthesis in sensitive plants, and exhibits concentration-dependent phytotoxicity to non-target maize seedlings. Fluazifop-P-butyl induces oxidative stress in male Wistar rats, impairs their liver and kidney functions, and disrupts testicular function^[1][2]. In Vitro:Fluazifop-P-butyl (0.65-65 μM; soaked for 1 min; grown for 7 days) inhibits shoot and root elongation of Zea mays var. saccharata L. cv. Złota Karłowa seedlings in a concentration-dependent manner, with roots showing higher sensitivity than shoots. It also regulates the levels of photosynthetic pigments in seedling leaves^[1]. In Vivo:Fluazifop-P-butyl (18.75-75.00 mg/kg; p.o.; daily; for consecutive 21 days) induces dose-dependent hepatotoxicity, nephrotoxicity, and oxidative stress-mediated testicular dysfunction in male Wistar rats^[2].