INCB3619
CAS No. : 791826-72-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $530 | In-stock |
| 10mg | $750 | In-stock |
| 25mg | $1300 | In-stock |
| 50mg | $1860 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-12636 |
| M.Wt: | 413.47 |
| Formula: | C22H27N3O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity[1].
In Vitro:INCB3619 (0-10 μM, 96 h) can inhibit heregulin-dependent HER3-Akt pathway, but not ERK activity in A549 cells, and induce apoptosis in A549 cells[1].
INCB3619 (0-10 μM, 72 h) can inhibit EGFR ligand signaling in the EGFR autocrine cell line NCI-H1666 and can be used in combination with other anti-EGFR drugs such as gefitinib[1].
INCB3619 (2 µM) inhibits ERK1/2 expression in NCI-H1666 and make it sensitive to Gefitinib (HY-50895)[1].
In Vivo:INCB3619 (subcutaneous injection, 60 mg/kg/d, 14 d) exhibits antitumor activity and sensitizes tumors to Gefitinib (HY-50895) in A549 xenografted BALB/c nu/nu mouse model[1].
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