Diammonium Glycyrrhizinate

Diammonium glycyrrhizinate is a substance that can be extracted and purified from a traditional Chinese medicinal herb. Diammonium glycyrrhizinate has anti-inflammatory effect, resistance to biologic oxidation, membranous protection and a weak steroidal action. Diammonium glycyrrhizinate exerts protective effect by downregulating inflammation cytokines, suppressing the NF-κB pathway, and restoring superoxide dismutase. Diammonium glycyrrhizinate can be used as a hepatic protector and can therefore be studied in research for most liver diseases^[1][2]. In Vitro:Diammonium glycyrrhizinate (Compound DG) (0.001 mg/mL, 1 h before Aβ_1-42) decreases the mRNA levels of TNF-α, COX-2, iNOS, and IL-1β increased by Aβ_1-42 (5 μM)^[4].
Diammonium glycyrrhizinate (0.001 mg/mL, 6-24 h) markedly increases the cell viability of HT22 and SH-SY5Y cell lines^[4]. In Vivo:Diammonium glycyrrhizinate (Compound DG) (40 mg/kg, i.p., every day for 1 week) significantly improves the inflammatory indices in SD rats received acetic acid^[1].
Diammonium glycyrrhizinate (75-200 mg/kg, i.p., 2 h before the Concanavalin A (HY-P2149) injection) inhibits the increase of both ALT and AST levels in liver-injury mice model^[2].
Diammonium glycyrrhizinate (131.69-2250 mg/kg, i.p., single dose) results in LD₅₀ values of 525.10 mg/kg and 997.26 mg/kg for male and female ICR mice^[3].
Diammonium glycyrrhizinate (15-120 mg/kg, i.p., single dose) returns the difference of the serum sodium with the addition of Oxymatrine (HY-N0158) (15-60 mg/kg) in ICR mice^[3].
Diammonium glycyrrhizinate (90 mg/kg, i.p., single dose) results in significantly higher serum sodium levels in ICR mice^[3].
Diammonium glycyrrhizinate (10 mg/kg/day, i.p., 14 d) significantly decreases the mRNA levels of COX-2, TNF-α, iNOS, and IL-1β whilst increasing mRNA level of IL-10 in AD mice^[4].
Diammonium glycyrrhizinate (150 mg/kg/day, i.p., alternate days for 14 w) remarkedly decreases the epididymal adipose tissues in HFD-fed C57BL/6J mice^[5].