Amino-PEG2-C2-acid
CAS No. : 791028-27-8
| Size | Price | Stock |
|---|---|---|
| 100mg | $11 | In-stock |
| 250mg | $14 | In-stock |
| 1g | $37 | In-stock |
| 5g | $136 | In-stock |
| 10g | $225 | In-stock |
| 25g | $495 | In-stock |
| 100g | $1317 | In-stock |
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| Cat. No. : | HY-W040168 |
| M.Wt: | 177.20 |
| Formula: | C7H15NO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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