(S)-(+)-N-3-Benzylnirvanol
CAS No. : 790676-40-3
(Synonyms: (+)-N-3-Benzylnirvanol)
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| Cat. No. : | HY-W013268 |
| M.Wt: | 294.35 |
| Formula: | C18H18N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(S)-(+)-N-3-Benzylnirvanol ((+)-N-3-Benzylnirvanol) is a selective and competitive cytochrome P450 (CYP) isoform CYP2C19 inhibitor with a Ki of 250 nM. (S)-(+)-N-3-Benzylnirvanol has low activity against CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, and CYP3A4[1].
In Vitro:In human liver preparations, (S)-(+)-N-3-Benzylnirvanol ((+)-N-3-Benzylnirvanol) inhibits (S)-mephenytoin 4'-hydroxylase activity, a marker for native microsomal CYP2C19, with Ki values ranging from 210 to 280 nM, respectively[1].
(S)-(+)-N-3-Benzylnirvanolthat (1 μM ) is used to examine inhibition of a panel of cDNA-expressed P450 isoforms, neither CYP1A2, 2A6, 2C8, 2C9, 2D6, 2E1, nor 3A4 activities are decreased by greater than 16%. In contrast, CYP2C19 activity is inhibited approximately 80%[1].
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