D-AP5
CAS No. : 79055-68-8
(Synonyms: D-APV; D-2-Amino-5-phosphonovaleric acid)
| Size | Price | Stock |
|---|---|---|
| 1mg | $38 | In-stock |
| 5mg | $80 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $343 | In-stock |
| 50mg | $585 | In-stock |
| 100mg | $805 | In-stock |
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| Cat. No. : | HY-100714A |
| M.Wt: | 197.13 |
| Formula: | C5H12NO5P |
| Purity: | >98 % |
| Solubility: | Ethanol : < 1 mg/mL (ultrasonic);H2O : 2 mg/mL (ultrasonic);DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) |
D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors[1][2].
IC50 & Target: NMDA[1]
In Vivo: D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented[2].
D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze[3].
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