Amorfrutin B
CAS No. : 78916-42-4
| Size | Price | Stock |
|---|---|---|
| 500μg | $347 | Get quote |
| 1mg | $554 | Get quote |
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| 10 mg | Get quote | |
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| Cat. No. : | HY-113631 |
| M.Wt: | 408.53 |
| Formula: | C26H32O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities[1][2].
In Vitro:Amorfrutin B (1,5 μM, 6 h) inhibits apoptosis and autophagy by gene methylation and miRNA-dependent regulation, and protects mouse brain neurons from hypoxia/ischemia[1].
In Vivo:Amorfrutin B (100 mg/kg, added to food for 2 weeks) improves insulin sensitivity, glucose tolerance and lipid concentration in insulin-resistant mice[2].
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