6-Thio-2'-Deoxyguanosine
CAS No. : 789-61-7
(Synonyms: 6-thio-dG; β-TGdR)
| Size | Price | Stock |
|---|---|---|
| 50mg | $158 | In-stock |
| 100mg | $268 | In-stock |
| 250mg | $457 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-18762 |
| M.Wt: | 283.31 |
| Formula: | C10H13N5O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. IC50 & Target: DNA/RNA Synthesis[1] In Vitro: Treatment with 6-Thio-2'-Deoxyguanosine results in rapid cell death for the vast majority of the cancer cell lines tested with IC50s of between 0.7-2.9 µM[1]. In Vivo: In A549 lung cancer cell-based mouse xenograft studies, 6-Thio-2'-Deoxyguanosine causes a decrease of the tumor growth rate, superior to that observed with 6-thioguanine treatment. Additionally, 6-Thio-2'-Deoxyguanosine increases telomere dysfunction in tumor cells in vivo[1].
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Inquiry Information- Product Name:
- 6-Thio-2'-Deoxyguanosine
- Cat. No.:
- HY-18762
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