COX-2-IN-1
CAS No. : 787623-48-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $315 | Get quote |
| 5 mg | Get quote | |
| 10 mg | Get quote | |
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| Cat. No. : | HY-U00275 |
| M.Wt: | 442.84 |
| Formula: | C18H14ClF3N4O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC50 of 3.9 μM. IC50 & Target: IC50: 3.9 μM (COX-2)[1] In Vitro: COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC50s of >100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound[1].
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