Amorolfine (hydrochloride)
CAS No. : 78613-38-4
(Synonyms: Ro 14-4767/002)
| Size | Price | Stock |
|---|---|---|
| 100mg | $106 | In-stock |
| 200mg | $159 | In-stock |
| 500mg | $285 | In-stock |
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| Cat. No. : | HY-B0238 |
| M.Wt: | 353.97 |
| Formula: | C21H36ClNO |
| Purity: | >98 % |
| Solubility: | H2O : 3.33 mg/mL (ultrasonic);DMSO : 12.5 mg/mL (ultrasonic) |
Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis[1][2].
In Vitro: Amorolfine hydrochloride acts primarily by inhibiting ergosterol biosynthesis, a component of fungal cell membrane, and possesses both fungistatic and fungicidal activity[1].
Amorolfine hydrochloride (0-128 mg/l) (2-7 days) shows anti-fungal activity for Dermatophyte fungi, Filamentous fungi, Pathogenic yeasts, Dimorphic fungi, Dematiaceous fungi[1].
Amorolfine hydrochloride shows anti-fungal activity with 90% killing corresponding concentrations of 3, 3, 10 and 100 mg/L for Trichophyton mentagrophytes, C. albicans, Histoplasma capsulatum, Cryptococcus neoformans, respectively[1].
In Vivo: Amorolfine hydrochloride (0.01%-1%; Intravaginal application; twice daily for 3 days) shows anti-fungal activity in rats with vaginal candidiasis[1].
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