Amino-PEG3-C2-acid
CAS No. : 784105-33-5
| Size | Price | Stock |
|---|---|---|
| 100mg | $11 | In-stock |
| 250mg | $17 | In-stock |
| 500mg | $25 | In-stock |
| 1g | $27 | In-stock |
| 5g | $135 | In-stock |
| 25g | $500 | In-stock |
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| 100 g | Get quote | |
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| Cat. No. : | HY-W040165 |
| M.Wt: | 221.25 |
| Formula: | C9H19NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C);DMF : 3.33 mg/mL (ultrasonic;warming;heat to 60°C) |
Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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