2'-Deoxy-2'-fluorouridine

2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research^[1][2][3][4]. In Vivo:2'-Deoxy-2'-fluorouridine (Compound 2’-FU) (0-500 mg/kg/day, i.v. parenterally via lateral tail, 90 consecutive days) results in dose dependent mean concentration in DNA, where the greatest in the liver and smallest in the testis of rat model^[4].
2'-Deoxy-2'-fluorouridine (0-7.5 mg/kg/day, i.v. parenterally via femoral vein, 90 consecutive days) results in dose-dependent concentrations in liver DNA of woodchucks^[4].