Dermorphin (TFA)
CAS No. : 78331-26-7
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| Cat. No. : | HY-P0244A |
| M.Wt: | 916.90 |
| Formula: | C42H51F3N8O12 |
| Purity: | >98 % |
| Solubility: | H2O |
Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1]. IC50 & Target:μ-opioid receptor (MOR)[1] In Vitro: Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor[2].
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