Rosiptor (acetate)
CAS No. : 782487-29-0
(Synonyms: AQX-1125 (acetate))
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| Cat. No. : | HY-109011A |
| M.Wt: | 381.55 |
| Formula: | C22H39NO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Rosiptor (AQX-1125) acetate is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor acetate (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro[1][2].
IC50 & Target:SHIP1[1]
In Vitro: Rosiptor acetate (0.1-10 μM; 30 minutes) inhibits Akt activation in MOLT-4, but not in Jurkat cells[1].
In Vivo: Rosiptor acetate (3-30 mg/kg; p.o.; daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity[2].
Rosiptor acetate (10 mg/kg; p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability[1].
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