DAMGO
CAS No. : 78123-71-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $55 | In-stock |
| 5mg | $99 | In-stock |
| 10mg | $176 | In-stock |
| 25mg | $374 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-P0210 |
| M.Wt: | 513.59 |
| Formula: | C26H35N5O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
DAMGO is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR[1].
IC50 & Target:Kd: 3.46±0.84 nM (native μ-OPR)[1]
In Vitro:DAMGO (1-10 μM) significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression[2].
DAMGO (1 μM) effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R I Na), i.e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO[3].
In Vivo:DAMGO (i.v., 0.5-2 mg/kg) can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect[4].
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