AZD-5672
CAS No. : 780750-65-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $266 | In-stock |
| 5mg | $584 | In-stock |
| 10mg | $818 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-119101 |
| M.Wt: | 632.78 |
| Formula: | C32H38F2N2O5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C) |
AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis[1][2][3].
IC50 & Target: IC50: 0.32 nM (CCR5) [1]; IC50: 7.3 μM (hERG)[1]; IC50: 32 μM (hP-gp)[2]
In Vitro: AZD-5672 (0, 0.1, 0.3, 1, 3, 10, 30, and 100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner (mean apparent IC50: 32 μM) in Caco-2 cells[2].
In Vivo: In vivo pharmaeokineties data for AZD-5672 (compound 1)[1]
| Species | CIa (mL/min/kg) |
Vssa (L/kg) | t1/2a (h) | Fb (%) |
| Rat | 28 | 5.3 | 2.6 | 38 |
| Dog | 18 | 5.7 | 3.9 | 86 |
a AZD-5672 dosed 1-2 mg/kg i.v.
b AZD-5672 dosed 2-5 mg/kg p.o.
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