CAY10397
CAS No. : 78028-01-0
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|---|---|---|
| 1mg | $130 | Get quote |
| 5mg | $557 | Get quote |
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| Cat. No. : | HY-119973 |
| M.Wt: | 328.32 |
| Formula: | C17H16N2O5 |
| Purity: | >98 % |
| Solubility: |
CAY10397 is a selective and orally active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor. CAY10397 can inhibit 15-PGDH-dependent endogenous metabolite production. CAY10397 blocks the selenium-dependent protective in inflammation. CAY10397 can be used for the research of colitis[1][2].
In Vitro:CAY10397 (50 μM; 10 min) potently inhibits 15-PGDH activity in LoVo cell lysates, reducing formation of 15-PGDH-dependent metabolites including 11-oxo-ETE by 92%[1].
CAY10397 (50 μM; 10 min) does not alter levels of 15-PGDH precursor metabolites in HCA-7 cell lysates, which express negligible 15-PGDH[1].
CAY10397 inhibits the activity of purified human recombinant 15-PGDH[2].
In Vivo:CAY10397 (100 mg/kg; i.g.; every other day) blocks the selenium-dependent protective effects against DSS (HY-116282C)-induced colitis, exacerbating inflammation, reducing gut barrier function, and inhibiting 15-PGDH activity[2].
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