Calcium hydrogen phosphate (dihydrate)

Calcium hydrogen phosphate dihydrate (Calcium phosphate dihydrate) can be found quite frequently in urinary calculi stones. Calcium hydrogen phosphate dihydrate can be used as an excipient, such as diluent, adsorbent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs^[1][2]. In Vitro:Calcium hydrogen phosphate dihydrate exhibits a low solubility in urine, which enables the easy precipitation and formation of crystals in urine, leading to kidney stones or bladder stones^[2][3].
Calcium hydrogen phosphate dihydrate acts as the precursor of hydroxyapatite and participates in the bone formation process^[3].
Calcium hydrogen phosphate dihydrate can be used as food additive in breakfast cereals, dog food, flour and noodles for calcium supplement^[3].
Calcium hydrogen phosphate dihydrate can be used as a tablet disintegrant in drug preparations^[3].