MK-0489
CAS No. : 778625-65-3
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| Cat. No. : | HY-11073 |
| M.Wt: | 600.18 |
| Formula: | C34H44ClF2N3O2 |
| Purity: | >98 % |
| Solubility: |
MK-0489 is an orally active, highly effective, and selective MC4R agonist. MK-0489 exhibits a strong binding affinity (IC50 = 13 nM) and functional agonist activity (EC50 = 4.6 nM) at human MC4R. MK-0489 shows functional activity of 22 nM (EC50) on mouse MC4R and 1.7 μM (EC50) on mouse MC3R. MK-0489 can be used for the study of obesity[1]. In Vivo:MK-0489 (Compound 1r) (2-20 mg/kg, p.o., once or twice daily for 14 days) specifically reduces food intake and body weight in mice via MC4R-mediated reduction, and in a dose-dependent manner, it reduces body weight in a diet-induced obese rat model[1].
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