GNF-5
CAS No. : 778277-15-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $44 | In-stock |
| 25mg | $88 | In-stock |
| 50mg | $133 | In-stock |
| 100mg | $200 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15738 |
| M.Wt: | 418.37 |
| Formula: | C20H17F3N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 49 mg/mL |
GNF-5, the N-hydroxyethyl carboxamide analog of GNF-2, is an orally active Bcr-Abl inhibitor. GNF-5 has Bcr-Abl inhibition activity with an IC50 value of 0.22 µM. GNF-5 has good favorable pharmacokinetic properties. GNF-5 can be used for the research of kinds of cancer including chronic myelogenous leukemia (CML) and breast cancer[1][2].
IC50 & Target: IC50: 0.22 µM (Abl)[1]
In Vitro: GNF-5 has inhibition of wild-type Abl with an IC50 value of 0.22 µM but no inhibition for myristate site mutant E505K (IC50 ＞10 µM)[1].
In Vivo: GNF-5 (5 mg/kg iv. or 20 mg/kg oral) has suitable pharmacokinetic parameters[1].
GNF-5 (oral, 50 or 100 mg/kg, twice daily, for 7 days) shows efficacious in vivo but can observe relapses[1].
GNF-5 (75 mg/kg, b.i.d) inhibits T315I Bcr-Abl combination with nilotinib in vivo[1].
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