Imeglimin
CAS No. : 775351-65-0
(Synonyms: EMD 387008)
| Size | Price | Stock |
|---|---|---|
| 5mg | $98 | In-stock |
| 10mg | $155 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $465 | In-stock |
| 100mg | $698 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14771 |
| M.Wt: | 155.20 |
| Formula: | C6H13N5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1]. IC50 & Target: ROS; mitochondrial function[1] In Vitro: Preincubation with Imeglimin (10?mM for 4?h or 100?μM for 24?h) fully prevents tert-butylhydroperoxide (tBH)-induced cell death[2]. In Vivo: Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, restores normal glucose tolerance, and improves insulin sensitivity[1].
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