Imeglimin (hydrochloride)
CAS No. : 775351-61-6
(Synonyms: EMD 387008 hydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $98 | In-stock |
| 10mg | $155 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $465 | In-stock |
| 100mg | $698 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-14771A |
| M.Wt: | 191.66 |
| Formula: | C6H14ClN5 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : ≥ 50 mg/mL |
Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1]. IC50 & Target: ROS; mitochondrial function[1] In Vitro: Preincubation with Imeglimin (10?mM for 4?h or 100?μM for 24?h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death[2]. In Vivo: Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance[1].
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