Acotiamide (monohydrochloride trihydrate)
CAS No. : 773092-05-0
| Size | Price | Stock |
|---|---|---|
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| 500mg | $85 | In-stock |
| 1g | $112 | In-stock |
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| Cat. No. : | HY-B2155 |
| M.Wt: | 541.06 |
| Formula: | C21H37ClN4O8S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : 3.03 mg/mL (ultrasonic;warming;heat to 60°C) |
Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory [1][2][3].
IC50 & Target: IC50: 1.79 μM (AChE)
In Vitro: Acotiamide monohydrochloride trihydrate (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines[1].
In Vivo: Acotiamide monohydrochloride trihydrate (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner[2].
Acotiamide monohydrochloride trihydrate (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with IC50 of 1.79 μM[3].
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