Hirsutine
CAS No. : 7729-23-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $260 | In-stock |
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| Cat. No. : | HY-N2193 |
| M.Wt: | 368.47 |
| Formula: | C22H28N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity[1][2][3]. In Vitro: Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC50 values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3[2]. In Vivo: Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells[3].
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