LU-32-176B
CAS No. : 770688-66-9
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| Cat. No. : | HY-118207 |
| M.Wt: | 398.45 |
| Formula: | C23H24F2N2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2]. IC50 & Target: LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2]. In Vivo: LU-32-176B (i.p.) and EF1502 can prevent sound-induced seizures in the Frings AGS-susceptible mouse model[1].
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