(24S,25)-Epoxycholesterol
CAS No. : 77058-74-3
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| Cat. No. : | HY-W040150 |
| M.Wt: | 400.64 |
| Formula: | C27H44O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
24S,25-Epoxycholesterol is an agonist for Liver X Receptor (LXR). 24S,25-Epoxycholesterol exhibits properties in regulating the cholesterol efflux[1], inhibiting tumor growth against gastric cancer and glioblastoma[2][3] and inducing apoptosis in BMMC cells[5].
In Vitro:24S,25-Epoxycholesterol (1-10 μM) upregulates the LXR-related genes ABCA1, ABCG1 and APOE, promotes the cholesterol efflux, therefore prevents the foam cell formation and blocks proliferation of mouse and human glioma stem-like cells through depeting cellular cholesterol[1][3].
24S,25-Epoxycholesterol inhibits proliferation and migration of HGC27, which is enhanced by knockout of LXRβ[2].
24S,25-Epoxycholesterol (40 μM) inhibits HMG-CoA reductase and activates the LXR, which suppresses mevalonate-dependent isoprenoid production and enhancing the ATP-binding cassette G1 expression, induces apoptosis in bone marrow-derived murine mast cells (BMMCs)[5].
In Vivo:24S,25-Epoxycholesterol (5 mM, icv) enhances the mDA neurogenesis, limits the neurodegeneration in CYP46A1-overexpressing mice midbrain[4].
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