Garcinone C
CAS No. : 76996-27-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-N6954 |
| M.Wt: | 414.45 |
| Formula: | C23H26O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active[1][2].
In Vitro:Garcinone C (1-5 μg/mL; 24 h-2 weeks) inhibits the the expression of cyclin D1, cyclin E and CDK6, increases the expression of p21, arrests the cell cycle at G0/G1 phase, inhibits the colony formation of HT29[2].
In Vivo:Garcinone C (10-50 mg/kg, po, 5 days per week for 9 weeks) exhibits antitumor activity in AOM (HY-111375)/DSS (HY-116282C)-induced colon cancer mouse models[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Garcinone C
- Cat. No.:
- HY-N6954
- Quantity:
Your information is safe with us.