Acipimox (sodium)
CAS No. : 76958-97-9
(Synonyms: K-9321 (sodium))
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| Cat. No. : | HY-B0283A |
| M.Wt: | 176.11 |
| Formula: | C6H5N2NaO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Acipimox (K-9321) sodium, a nicotinic acid analogue, is an antilipolytic compound. Acipimox sodium stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity[1][2][3].
In Vitro: Acipimox sodium (0-100 µM; 0-4 hours) enhances leptin release from adipocytes isolated from Sprague-Dawley rats in a time- and dose- dependent manner[2].
Acipimox sodium (10 mM) stimulats leptin release in adipocytes from Streptozotocin (STZ)-treated and Zucker diabetic fat (ZDF) rats[2].
In Vivo: Acipimox sodium (50 mg/kg; i.p.) significantly lowers circulating free fatty acid (FFA) and glucose in high-fat fed mice[3].
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