Perillic acid
CAS No. : 7694-45-3
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| Cat. No. : | HY-113471 |
| M.Wt: | 166.22 |
| Formula: | C10H14O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Perillic acid is the metabolite of Perillyl alcohol (HY-N7000). Perillic acid induces lung cancer cell cycle arrest and apoptosis. Perillic acid shows anti-HSV-1 and immunomodulatory activities[1][2][3].
In Vitro: Perillic acid (1-5 mM; 24 h) decreases A549 cells survival in a dose-dependent manner[1].
Perillic acid (1 mM; 24 h) induces S-phase arrest in A549 cells and induces G2/M arrest in H520 cells[1].
Perillic acid (2 mM; 24 h) induces A549 and H520 cells apoptosis[1].
Perillic acid (0-50 μM; 24 h) shows potential antiviral activity primarily against the 17syn+ HSV-1 strain (EC50 KOS: 2.84 μM; 17syn+: 1.08 μM)[2].
In Vivo: Perillic acid (50 μM/kg; i.p.; daily for 5 days) shows immunomodulatory activity in mice[3].
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