8-Bromo-cAMP sodium salt
CAS No. : 76939-46-3
(Synonyms: 8-Br-Camp sodium salt)
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|---|---|---|
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| 10mg | $70 | In-stock |
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| 50mg | $185 | In-stock |
| 100mg | $280 | In-stock |
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| Cat. No. : | HY-12306 |
| M.Wt: | 430.08 |
| Formula: | C10H10BrN5NaO6P |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL;H2O : 100 mg/mL (ultrasonic) |
8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells[1][2].
IC50 & Target:PKA[1]
In Vitro:8-Bromo-cAMP (0.1/0.5 mM) sodium salt enhances the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells, and 0.1 mM of 8-Bromo-cAMP shows a synergistic effect with Valproic acid (HY-10585) (0.5 mM)[1].
8-Bromo-cAMP (20 μM, 24 and 48 h) sodium salt induces apoptosis in esophageal cancer cell line (Eca-109)[2].
8-Bromo-cAMP (0.5 mM, 2 days) sodium salt induces decidualization of human endometrial stromal cells[3].
In Vivo:8-Bromo-cAMP (60 mg/kg/day, i.p., 7 days) sodium salt reduces tumor in CT26 tumor mice[4].
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