Natamycin

Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research^[1][2]. In Vitro: Natamycin, an important macrolide antibiotic, produced by several Streptomyces species, including S. natalensis, S. gilvosporeus, S. lydicus and S. chattanoogensis, can inhibit the growth of fungi via immediate inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is widely used in the food industry and in pharmacotherapy for topical treatment. Unlike other polyene antibiotics, the mode of action of Natamycin is not based on the ergosterol-dependent permeabilization of the plasma membrane. The immediate cessation of growth of yeasts by Natamycin treatment indicates that there might be an instantaneous effect of Natamycin at the level of the plasma membrane^[1][2].