Ronidazole
CAS No. : 7681-76-7
| Size | Price | Stock |
|---|---|---|
| 100mg | $25 | In-stock |
| 500mg | $51 | In-stock |
| 1g | $80 | In-stock |
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| Cat. No. : | HY-B0565 |
| M.Wt: | 200.15 |
| Formula: | C6H8N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 4 mg/mL (ultrasonic) |
Ronidazole is a potent and orally active antiprotozoal and anti-microbial agent. Ronidazole acts as a veterinary agent against Tritrichomonas foetus in cats models. Ronidazole can be used the research of forhistomoniasis and swine dysentery[1][2][3].
In Vitro:Ronidazole (0.0625-0.25 μg/mL;48 hours) can effectively inhibit the growth of C. difficile all 24 strains, and the MIC50 and MIC90 values are 0.125 μg/mL.[2].
Ronidazole (0.3125 μg/mL, 1.25 μg/mL; 8 hours) can reduce the C. difficile bacteria count to below the detection limit, and has concentration-dependent bactericidal activity against C. difficile bacteria[2].
In Vivo:
Pharmacokinetic Analysis in six cats[3]
| Drug administration | Dose (mg/kg) | T1/2 (K) (h) | C0 (μg/mL) | AUC 0-∞ (h•μg/m) | Vd or Vd/F (mL/kg) | Clearance or CL/F (h) | MRT (h) | Tmax (h) | Cmax (μg/m) | F (%) |
| i.v. | 9.175 | 9.80 | 13.27 | 187.30 | 700 | 0.82 | 14.14 | NA | NA | NA |
| p.o. | 28.23 | 10.50 | NA | 566.98 | 770 | 0.84 | NA | 1.02 | 35.37 | 99.64 |
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