Amantadine
CAS No. : 768-94-5
(Synonyms: 1-Adamantanamine; 1-Aminoadamantane)
| Size | Price | Stock |
|---|---|---|
| 25g | $10 | In-stock |
| 100g | $23 | In-stock |
| 500g | $103 | In-stock |
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| Cat. No. : | HY-B0402 |
| M.Wt: | 151.25 |
| Formula: | C10H17N |
| Purity: | >98 % |
| Solubility: | DMSO : 6.48 mg/mL (ultrasonic;warming;adjust pH to 4 with 1 M HCL;heat to 60°C) |
Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].
In Vitro:Amantadine (0-500 μM, 26 h) inhibits SARS-CoV-2 replication, with IC50 concentrations between 83 and 119 μM[4].
Amantadine (0-100 μg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC?7721 cells[6].
Amantadine (0-75 μg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis[6].
Amantadine (0-75 μg/mL, 48 h) reduces the levels of the cell cycle?related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels[6].
In Vivo:Amantadine (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment[5].
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