Pyronaridine (tetraphosphate)
CAS No. : 76748-86-2
| Size | Price | Stock |
|---|---|---|
| 50mg | $55 | In-stock |
| 100mg | $77 | In-stock |
| 250mg | $154 | In-stock |
| 500mg | $264 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-14749A |
| M.Wt: | 910.03 |
| Formula: | C29H44ClN5O18P4 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[1][2].
In Vitro: Pyronaridine tetraphosphate (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM[1].
In Vivo: Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) tetraphosphate reduces the parasitic burden in the Echinococcus granulosus-infected mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) tetraphosphate reduces the parasitic burden in secondarily infected (cysts) mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) tetraphosphate exhibits a higher exposure in the liver than in the plasma in male ICR mice[2].
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