Histrelin
CAS No. : 76712-82-8
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| Cat. No. : | HY-P0056 |
| M.Wt: | 1323.50 |
| Formula: | C66H86N18O12 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis[1][2][5].
IC50 & Target:GnRH Receptor[1]
In Vitro:Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants[4].
Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system[5].
In Vivo:Histrelin (0.1 mg/kg, subcutaneous injection) rescues the circulating LH concentrations in Csfmop/Csfmop mice[2].
Histrelin (10,30, or 100 μg /day, subcutaneous injection) reduces the number of endometrial glands and atrophied the stroma in rabbits[3].
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