Size | Price | Stock |
---|---|---|
1mg | $60 | In-stock |
5mg | $130 | In-stock |
10mg | $220 | In-stock |
25mg | $450 | In-stock |
50 mg | Get quote | |
100 mg | Get quote | |
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Cat. No. : | HY-100227 |
M.Wt: | 314.38 |
Formula: | C15H26N2O5 |
Purity: | >98 % |
Solubility: | DMSO : 250 mg/mL (795.22 mM; Need ultrasonic) |
E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV. IC50 & Target: Cysteine proteases[1], CANP[2], Cathepsin C[3]. In Vitro: E-64c, a derivative of naturally occurring epoxide inhibitor of cysteine proteases, with papain; especially with regard to the hydrogen bonding and hydrophobic interactions of the ligands with conserved residues in the catalytic binding site[1]. E 64c (k2/Ki=140±5M-1s-1) is demonstrated to be a lead structure for the development of irreversible cathepsin C inhibitors[3]. In Vivo: The t-1/2 of plasma E-64c is 0.48 hours. The hemodynamic effects of E-64c are absent at this dose. Using two way analysis of variance, the effects of reperfusion (p=0.0016) or E-64c (p=0.0226) per se on infarct size are significant. In comparing Group A with Group B and Group C with Group D, the depletion of CPK in the E-64c treated groups (Groups A and C) is slightly less than in the vehicle-injected groups (Groups B and D). The insufficient effect of E-64c alone may be explained by the early administration and relatively short t-1/2. Since the effectiveness of NCO-700 has been established,6),7) our findings might indicate a small but beneficial effect of E-64c on infarct size and CPK content[2].
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