Cyclic GMP
CAS No. : 7665-99-8
| Size | Price | Stock |
|---|---|---|
| 25mg | $97 | In-stock |
| 50mg | $130 | In-stock |
| 100mg | $156 | In-stock |
| 250mg | $260 | In-stock |
| 1g | $610 | In-stock |
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| Cat. No. : | HY-113469 |
| M.Wt: | 345.21 |
| Formula: | C10H12N5O7P |
| Purity: | >98 % |
| Solubility: | H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses[1][2][3][4].
In Vitro:ACh can stimulate the accumulation of cyclic GMP (cGMP), thereby activating cGMP-mediated protein kinases. Increased cGMP causes a decrease in Ca ion influx, which shortens the action potential and inhibits ICa. Cyclic GMP (1 μM; 3-5 min) can activate cGMP-stimulated phosphodiesterases when acting synergistically with Isoprenaline (HY-B0468), reversing cAMP-mediated enhancement or inhibiting cAMP-induced inward calcium current (ICa)[3].
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