SMK-17


CAS No. : 765958-29-0

765958-29-0
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Cat. No. : HY-12447
M.Wt: 584.85
Formula: C20H24ClF2IN4O2S
Purity: >98 %
Solubility:
Introduction of 765958-29-0 :

SMK-17 is a selective, non-ATP-competitive MEK1/MEK2 inhibitor with IC50s of 62 nM and 56 nM, respectively. SMK-17 binds to the allosteric pocket of MEK1/2. SMK-17 induces apoptosis in tumor cell lines harboring β-catenin mutations[1].

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