Ambenonium
CAS No. : 7648-98-8
(Synonyms: WIN 8077)
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| Cat. No. : | HY-118533 |
| M.Wt: | 537.56 |
| Formula: | C28H42Cl2N4O2 2+ |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ambenonium is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium inhibits human AChE with an IC50 value of 0.7 nM (hAChE)[1][2].
IC50 & Target:IC50: 0.7 nM (hAChE), 7 μM (hBChE)[1]
In Vitro: Ambenonium inhibits Acetyicholinesterase (AChE) in a rapidly reversible method, and shows strong inhibition with inhibition constant Ki of 0.12 nM against hAChE[1].
Ambenonium shows inhibitory effect towards BChE with an IC50 value of 7 μM (hBChE)[2].
In Vivo: Ambenonium (6 mg/kg; p.o.; daily; 30-60 d) results an adverse effect on neuromuscular transmission in long-term administration, and induces hypersensitivity to stimulation in myasthenia gravis mice modle[3].
Ambenonium (6 mg/kg; p.o.; daily; 14 d) decreases the number of AChR in motorend-plates[3].
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