D-Erythro-dihydrosphingosine
CAS No. : 764-22-7
(Synonyms: Sphinganine (d18:0))
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $360 | In-stock |
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| Cat. No. : | HY-W019838 |
| M.Wt: | 301.51 |
| Formula: | C18H39NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C);Ethanol : 50 mg/mL (ultrasonic) |
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity. In Vitro: D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na3VO4-, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [3H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA2α activity[1].
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