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HY-10162

CAS:763113-22-0

 (Synonyms  AZD2281;KU0059436)
763113-22-0  Technical Data: Price and Availability of  Cas No:763113-22-0

Cas : 763113-22-0 M.Wt: 434.4628
Cas : 763113-22-0 Formula: C24H23FN4O3
Cas : 763113-22-0 Purity: >98 %
Cas : 763113-22-0 Storage: at 20℃ 2 years
Cas : 763113-22-0 Solubility: DMSO: 29 mg/mL; in vivo: dissolved in DMSO (31.25 mg/mL) and then diluted with PBS (DMSO: PBS=1:9)
Cas : 763113-22-0 Name: Olaparib
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2g/$450 In-stock
5g/$850 In-stock
10mg/$50 In-stock
10g/$1600 In-stock
50mg/$70 In-stock
100mg/$90 In-stock
200mg/$120 In-stock
500mg/$180 In-stock
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763113-22-0  Data Sheet:
 
Introduction of 763113-22-0 :
Olaparib is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP-1 and PARP-2, respectively. IC50 & Target: IC50: 5/1 nM (PARP-1/2)[1] In Vitro: Olaparib (AZD2281) is a single digit nanomolar inhibitor of both PARP-1 and PARP-2 that shows standalone activity against BRCA1-deficient breast cancer cell lines. Olaparib is applied to SW620 cell lysates, and identified the IC50 for PARP-1 inhibition to be around 6 nM and the total ablation of PARP-1 activity to be at concentrations of 30?100 nM[1]. In Vivo: Animals bearing SW620 xenografted tumors are treated with Olaparib (10 mg/kg, p.o.) in combination with Temozolomide (TMZ) (50 mg/kg, p.o.) once daily for 5 consecutive days, after which the tumors are left to grow out[1]. Olaparib increases vascular perfusion in Calu-6 tumors established in a DWC model. Administration of olaparib(50 mg/kg, p.o.) as a single agent (top panel) or in combination with radiation (bottom panel) results in an increase in fluorescence intensity in the Calu-6 tumors[2].
 
References on 763113-22-0 :
 

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