XR9051
CAS No. : 762219-35-2
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| Cat. No. : | HY-13776 |
| M.Wt: | 642.74 |
| Formula: | C39H38N4O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
XR9051 is an orally active and specific modulator of P-glycoprotein-mediated multidrug resistance (MDR)[1].
In Vitro: XR9051 is able to reverse resistance to a variety of cytotoxic drugs, including doxorubicin, etoposide and vincristine, which are associated with classical MDR[1].
XR9051 is highly active and gave at least a 15- to 20- fold decrease in the doxorubicin IC50, in the acquired resistance cell lines[1].
In Vivo: XR9051 (20-40 mg/kg, ip) shows significant modulatory activity in mice bearing MDR human ovarian (2780AD and CH1/DOXr) and SCLC (H69/LX) xenografts[2].
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