Derrone
CAS No. : 76166-59-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $230 | Get quote |
| 5mg | $570 | Get quote |
| 10 mg | Get quote | |
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| Cat. No. : | HY-N3737 |
| M.Wt: | 336.34 |
| Formula: | C20H16O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity[1][2].
IC50 & Target: IC50: 6 μM (Aurora kinase B), 22.3 μM (Aurora kinase A)[1]
In Vitro: Derrone (30-60 μM, 15 days) significantly inhibits the formation and growth of MCF7 tumor spheroids, with the tumor spheroid growth inhibition (% TGI) of 17.5% and 65.4% for 30 and 60?μM Derrone, respectively[1].
Derrone shows the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62)[2].
Derrone induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells[2].
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